Departamento de Ingeniería Biomédica

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https://hdl.handle.net/1992/52212
Encuentre en acceso abierto la producción académica, investigativa y de creación del Departamento de Ingeniería Biomédica de la Universidad de los Andes.

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    Detection of pathogens causing fever of unknown origin and co-circulating with SARS CoV 2 using a portable and lowcost device
    (Universidad de los Andes, 2022-07-28) Gómez León, Laura Andrea; Restrepo Restrepo, Silvia; González Rosas, Camila; Cordovez Álvarez, Juan Manuel; 39784728; 52393017; 80505711; Bernal Giraldo, Adriana Jimena; Bloch Morel, Natasha Ivonne
    Infectious diseases are caused by bacteria, viruses, parasites, and fungi. These diseases can be transmitted, directly or indirectly, from one person to another. In Colombia, there are around 150 infectious diseases under surveillance according to the Ministry of Health and the National Institute of Health. These diseases can be diagnosed using multiple laboratory techniques, including culture, antigen detection methods, nucleic acid detection, and serology. However, many of these traditional diagnostic techniques, especially culture, are time-consuming, expensive, and often require sophisticated equipment, trained personnel, and specific conditions to perform. Therefore, this project aimed to standardize a low-cost and time-saving technique for detecting parasites and viruses that cause different infectious diseases. For this purpose, using the PLUM device, LAMP and ELISA techniques were implemented for the detection of nucleic acids and antibodies in nasopharyngeal swab samples and serum from different regions of the country to evaluate the presence of Leishmaniasis, Zika, Dengue, and Chikungunya, highly prevalent diseases in Colombia. From the tests, it was possible to verify that these techniques through a portable device can be implemented in rural areas, with low resources and/or far from diagnostic centers. It also has several advantages over currently existing techniques, reducing processing times from three hours to one hour and reducing costs from $150 a molecular test to around $2, representing an advantage for monitoring and treatment. timing of infectious diseases.